辅助生殖技术
危险系数
卵胞浆内精子注射
医学
儿科
自闭症谱系障碍
注意缺陷多动障碍
生殖技术
多胞胎
怀孕
队列
体外受精
置信区间
自闭症
精神科
不育
环境卫生
人口
内科学
生物
遗传学
哺乳期
作者
Kristiina Rönö,E. Rissanen,Christina Bergh,Ulla‐Britt Wennerholm,Signe Opdahl,Liv Bente Romundstad,Anna-Karina Aaris Henningsen,Anne Lærke Spangmose,Anja Pinborg,Mika Gissler,Aila Tiitinen
标识
DOI:10.1016/j.fertnstert.2022.01.010
摘要
To assess the risk of neurodevelopmental disorders in singletons born after the use of assisted reproductive technology (ART) compared with singletons born without the use of ART.Nordic register-based study.Cross-linked data from Medical Birth Registers and National ART and Patient Registers; liveborn singletons in 1995-2014 in Denmark and Finland, 2005-2015 in Norway, and 1995-2015 in Sweden with follow-up to 2014 (Denmark and Finland) or 2015 (Norway and Sweden).A total of 5,076,444 singletons: 116,909 (2.3%) born with and 4,959,535 (97.7%) born without the use of ART (non-ART).In vitro fertilization, intracytoplasmic sperm injection, and fresh and frozen embryo transfer.The primary outcomes (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, codes) were learning and motor functioning disorders (F80-F83), autism spectrum disorder (F84), attention-deficit/hyperactivity disorder and conduct disorders (F90-F92), and tic disorders (F95). Crude hazard ratios (HRs) and adjusted hazard ratios (aHRs) with 95% confidence intervals were calculated.Singletons in the ART cohort had a higher adjusted risk of learning and motor functioning disorders (HR, 1.01 [0.96-1.07]; aHR, 1.17 [1.11-1.24]) and a tendency toward a higher risk of autism spectrum disorder (HR, 1.12 [1.04-1.21]; aHR, 1.07 [0.98-1.16]) and attention-deficit/hyperactivity disorder and conduct disorders (HR, 0.82 [0.77-0.86]; aHR, 1.17 [0.99-1.12]) but not of tic disorders (HR, 1.21 [1.06-1.38]; aHR, 1.17 [0.96-1.27]). No differences in risk were found between children born after in vitro fertilization and intracytoplasmic sperm injection or after fresh and frozen embryo transfer.Our findings of only small differences in neurodevelopment between ART and non-ART singletons are reassuring and in line with previous studies.
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