Erythema Multiforme, Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Erythema multiforme (EM), Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a group of mucocutaneous diseases characterized by varying degrees of skin and mucosal involvement, with the latter two conditions associated with high morbidity and mortality. EM is typically caused by infections, especially herpes simplex virus. Patients present with target lesions with or without mucosal involvement. This is a self-limiting disease. SJS and TEN are characterized by cutaneous desquamation and mucosal involvement. They have a higher morbidity than EM. Medications and infections are the most common causes of SJS/TEN.