胰岛素抵抗
牙周炎
医学
内科学
糖尿病
混淆
稳态模型评估
内分泌学
临床附着丧失
胰岛素
胃肠病学
作者
Lorena Lúcia Costa Ladeira,Fábio Renato Manzolli Leite,Gustavo G. Nascimento,Maria da Conceição Pereira Saraiva,Mario Brondani,Ana Regina Oliveira Moreira,Cecília Cláudia Costa Ribeiro
出处
期刊:Oral Diseases
[Wiley]
日期:2022-07-12
卷期号:29 (8): 3630-3639
被引量:2
摘要
To investigate the association between insulin resistance markers and periodontitis in adolescents, analyzing confounder variables and the adiposity as a mediator.This is population-based study is representative of adolescents aged 17-18 years from public schools in São Luís, Brazil (n = 405). Insulin resistance was assessed using the Model of Assessment of the Homeostasis of the Insulin Resistance Index (HOMA-IR) and its percussor triglycerides/HDL-cholesterol ratio (TG/HDL-c). The outcome was Initial Periodontitis, a latent variable estimated by the common variance shared among bleeding on probing, probing depth ≥ 4 mm, and clinical attachment loss ≥ 4 mm. The association between insulin resistance and Initial Periodontitis was modeled via pathways triggered by socioeconomic status, smoking, alcohol, and Adiposity, using structural equation modeling.Higher TG/HDL-c was directly associated with higher Initial Periodontitis (standardized coefficient [SC] = 0.130, p < 0.001). HOMA-IR was not associated with periodontal outcome (SC = 0.023, p = 0.075), but it was with Adiposity (SC = 0.495, p < 0.001). Higher TG/HDL-c was associated with Adiposity (SC = 0.202, p < 0.001).The insulin resistance markers were associated with early signs of periodontal breakdown among adolescents, suggesting a possible relationship between diabetes and periodontitis commences early in life.
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