痴呆
载脂蛋白E
阿尔茨海默病神经影像学倡议
医学
脑脊液
磁共振成像
内科学
队列
一致性
生物标志物
正电子发射断层摄影术
人口
萎缩
肿瘤科
病理
疾病
核医学
化学
生物化学
放射科
环境卫生
作者
Feng Gao,Xinyi Lv,Linbin Dai,Qiong Wang,Peng Wang,Zhaozhao Cheng,Qiang Xie,Ming Ni,Yan Wu,Xianliang Chai,Wenjing Wang,Huaiyu Li,Feng Yu,Yuqin Cao,Fang Tang,Bo Pan,Guoping Wang,Kan Deng,Shi‐Cun Wang,Qihe Tang,Jiong Shi,Yong Shen
摘要
To test the utility of the "A/T/N" system in the Chinese population, we study core Alzheimer's disease (AD) biomarkers in a newly established Chinese cohort.A total of 411 participants were selected, including 96 cognitively normal individuals, 94 patients with mild cognitive impairment (MCI) patients, 173 patients with AD, and 48 patients with non-AD dementia. Fluid biomarkers were measured with single molecule array. Amyloid beta (Aβ) deposition was determined by 18 F-Flobetapir positron emission tomography (PET), and brain atrophy was quantified using magnetic resonance imaging (MRI).Aβ42/Aβ40 was decreased, whereas levels of phosphorylated tau (p-tau) were increased in cerebrospinal fluid (CSF) and plasma from patients with AD. CSF Aβ42/Aβ40, CSF p-tau, and plasma p-tau showed a high concordance in discriminating between AD and non-AD dementia or elderly controls. A combination of plasma p-tau, apolipoprotein E (APOE) genotype, and MRI measures accurately predicted amyloid PET status.These results revealed a universal applicability of the "A/T/N" framework in a Chinese population and established an optimal diagnostic model consisting of cost-effective and non-invasive approaches for diagnosing AD.
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