Overcoming peri- and ortho-selectivity in C–H methylation of 1-naphthaldehydes by a tunable transient ligand strategy

This work provides a highly regioselective peri - and ortho -C–H methylation of 1-naphthaldehyde by using a transient ligand strategy, enabling practical synthesis of multi-substituted naphthalene-based bioactive molecules and natural products.