Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2

(Cell Reports 38, 110409, February 22, 2022) Due to an oversight, in the originally published version of this article, the graphical abstract contained an error in which the arrow between GLN and GLU was in the wrong direction. The corrected graphical abstract now appears with the article online, and the original and corrected graphical abstract appear here. Cell Press and the authors regret this error.(Original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2Cicatiello et al.Cell ReportsFebruary 22, 2022In BriefUsing molecular, biochemical, and isotope-tracing approaches combined with mass spectrometry and denervation experiments, Cicatiello et al. demonstrate that thyroid hormones (THs) drive a rewiring of glutamine metabolism in skeletal muscle, resulting in protection from atrophy, and identify GPT2 as a critical mediator of the TH-dependent anabolic function. Full-Text PDF Open Access