支气管肺发育不良
医学
胎龄
单变量分析
新生儿重症监护室
妊娠期
逻辑回归
插管
儿科
前瞻性队列研究
队列
出生体重
多元分析
内科学
怀孕
麻醉
遗传学
生物
作者
Patricia Lee Woods,Benjamin Stoecklin,Amanda Woods,Andrew W. Gill
出处
期刊:Archives of Disease in Childhood-fetal and Neonatal Edition
[BMJ]
日期:2021-05-11
卷期号:106 (6): 657-662
被引量:3
标识
DOI:10.1136/archdischild-2020-320830
摘要
Objective To test the hypothesis that lung ultrasound (LUS) performed in the first week of life would predict bronchopulmonary dysplasia (BPD). Secondary outcomes included the utility of LUS in predicting interim respiratory interventions. Design A prospective observational cohort study in preterm infants born <28 weeks’ gestation in the single tertiary statewide neonatal intensive care unit in Western Australia. Methods A rigorous protocol for LUS acquisition on day 1, day 3–4, day 7, day 28 and 36 weeks’ postmenstrual age (PMA) was implemented with blinded analysis using a modified, previously validated LUS score. BPD was defined by both recent National Institute of Child Health and Human Development categorical criteria and a continuous physiological variable using a modified Shift test. Results Of the 100 infants studies, primary outcome data were available for the 96 infants, surviving to 36 weeks’ PMA. In a univariate logistic regression analysis, LUS on days 3–4 and day 7 accurately predicted BPD (day 3–4 OR (95% CI)=1.54 (1.03 to 2.42), p=0.044; day 7 OR (95% CI)=1.66 (1.07 to 2.70), p=0.031). The predictive value of LUS was insignificant in a multivariate model in which gestational age was the dominant predictor. LUS accurately predicted interim respiratory outcomes including surfactant administration, duration of intubation and extubation to non-invasive support at 48 hours. Conclusions LUS in the first week of life predicted BPD. However, LUS offers little additive accuracy to current gestational age-based models. Trial registration number ACTRN12617000208303.
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