呋喃妥因
磷霉素
抗生素耐药性
抗菌剂
环丙沙星
微生物学
抗生素
抗菌管理
医学
甲氧苄啶
头孢吡肟
肺炎克雷伯菌
头孢菌素
抗药性
大肠杆菌
生物
亚胺培南
基因
生物化学
作者
Antonio Milano,Adela Sulejmani,Jari Intra,Maria Roberta Sala,Valerio Leoni,Davide Carcione
出处
期刊:Microbial Drug Resistance
[Mary Ann Liebert]
日期:2022-01-01
卷期号:28 (1): 63-72
被引量:9
标识
DOI:10.1089/mdr.2021.0010
摘要
Antimicrobial resistance is a worldwide problem, and resistance in Enterobacteriaceae, particularly Escherichia coli and Klebsiella pneumoniae, is a critical threat to human health. Inappropriate and unnecessary use of antibiotics in human health care is the most common cause for the development and spread of antimicrobial resistance. In this work, we retrospectively analyzed the antimicrobial data of E. coli strains isolated from midstream urinary samples over a 20-year period (2000-2019). The aim was to provide useful information to clinicians to prescribe a more appropriate empirical antibiotic therapy. A total of 30,955 unique E. coli isolates from positive midstream urine samples of inpatients (1,198) and outpatients (29,757) were collected. Except for carbapenems, over time all the antibiotics tested showed increasing resistance rates in both groups (p < 0.0001). On the other hand, fosfomycin and nitrofurantoin presented significant decreasing trends in resistance rate (p < 0.05). There were significant increases in extended-spectrum β-lactamases- and multidrug resistance positive isolates starting in 2000 (p < 0.0001), with similar results in both groups. Ciprofloxacin, gentamicin, trimethoprim/sulfamethoxazole, and third-generation cephalosporin resistances significantly increased with increasing age (p < 0.0001). Collectively, E. coli resistance rates severely increased during the study period, except for fosfomycin and nitrofurantoin. The need of monitoring studies about antibiotic nonsusceptibilities at local and regional levels are necessary to enhance the focus on antimicrobial stewardship, to reduce antimicrobial consumption and to detect alarming resistance mechanisms.
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