间充质干细胞
内皮
内皮功能障碍
疾病
内皮干细胞
医学
表型
细胞生物学
心脏病学
病理
内科学
生物
体外
遗传学
基因
作者
Qingyan Huang,Yuhong Gan,Zhikang Yu,Heming Wu,Zhixiong Zhong
标识
DOI:10.3389/fcvm.2021.734550
摘要
Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high morbidity and mortality worldwide. The endothelium is the first protective barrier in atherosclerosis. Endothelial cells have the potential to be transformed into mesenchymal cells, in a process termed endothelial to mesenchymal transition (EndMT). On the one hand, EndMT is known to contribute to atherosclerosis by inducing a number of phenotypes ranging from endothelial cell dysfunction to plaque formation. On the other hand, risk factors for atherosclerosis can lead to EndMT. A substantial body of evidence has suggested that EndMT induces the development of atherosclerosis; therefore, a deeper understanding of the molecular mechanisms underlying EndMT in atherosclerosis might provide insights to reverse this condition.
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