子宫内膜异位症
病因学
不育
盆腔疼痛
重症监护医学
生物
生物信息学
临床试验
医学
妇科
内科学
怀孕
外科
遗传学
作者
Philippa T. K. Saunders,Andrew W Horne
出处
期刊:Cell
[Elsevier]
日期:2021-05-01
卷期号:184 (11): 2807-2824
被引量:257
标识
DOI:10.1016/j.cell.2021.04.041
摘要
Endometriosis is a common condition associated with infertility that causes chronic pain in many, but not all, women. It is defined by the presence of endometrial-like tissue outside the uterus. Although the cause and natural history of the disorder remain uncertain, hormonal, neurological, and immunological factors are all implicated in the mechanisms contributing to development of symptoms. Because definitive diagnosis requires surgery, there is often a long diagnostic delay after onset of symptoms. Current interventions for endometriosis have limited efficacy and unacceptable side effects/risks and are associated with high rates of symptom recurrence. Here, we review recent advances in our understanding of the etiology of endometriosis, discuss current diagnostic and treatment strategies, highlight current clinical trials, and consider how recent results offer new avenues for the identification of endometriosis biomarkers and the development of effective non-surgical therapies that are fertility-sparing.
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