骨关节炎
炎症
单调的工作
医学
茴香霉素
NF-κB
促炎细胞因子
内科学
肿瘤坏死因子α
物理疗法
化学
激酶
病理
生物化学
替代医学
作者
Liang Chen,Yiting Lou,Zheqiang Pan,Xia Cao,Leyong Zhang,Chang Zhu,Jinxi Liang
标识
DOI:10.1016/j.bbrc.2019.12.014
摘要
Osteoarthritis (OA) remains a challenge for clinicians and effective treatments are lacking. In this study, we investigated JNK/NF-κB signaling in knee OA patients. Rats were used to establish an OA model and were divided into six groups; (1) Control (sterile saline injection only); (2) Controls with treadmill exercise (treadmill); (3) Controls with wheel exercise (wheel); (4) OA (MIA injection); (5) OA with treadmill exercise (OA + treadmill); and (6) OA with wheel exercise (OA + wheel). The results showed that, compared to the OA group, the OA + treadmill and OA + wheel groups had lower levels of IL-1β, IL-6 and TNF-α, and similar levels of p-P65, p-JNK, and P-IκBα. Furthermore, treatment with the JNK agonist anisomycin enhanced the damage to the joint cartilage and increased the levels of IL-1β, IL-6 and TNF-α. Taken together, these data suggest that treadmill and wheel exercise protect against inflammation through the regulation of JNK/NF-κB signaling in experimental models of knee OA.
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