Headache and impaired consciousness level associated with SARS-CoV-2 in CSF

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main clinical features include fever, cough, and dyspnea; however, in a recent series, diarrhea (19.2%), headache (13.1%), and impaired consciousness (7.5%) were also frequent symptoms.1 Rare associations like Miller-Fisher syndrome2 or encephalitis3 have been recently reported. However, to date, there are few studies demonstrating the presence of SARS-CoV-2 in CSF and neurologic symptoms.3