光热治疗
免疫疗法
胶体金
癌症研究
免疫系统
转移
黑色素瘤
癌症免疫疗法
癌症
纳米颗粒
材料科学
化学
医学
抗原
纳米技术
免疫学
内科学
作者
Dan Zhang,Tingting Wang,Xianya Qin,Qi Qiao,Lihuan Shang,Qingle Song,Conglian Yang,Zhiping Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2019-08-08
卷期号:19 (9): 6635-6646
被引量:163
标识
DOI:10.1021/acs.nanolett.9b02903
摘要
Gold nanoparticle (AuNP) has been widely used in cancer photothermal therapy (PTT) for ablating accessible tumor, while it is insufficient for inhibiting tumor metastasis and relapse in current stage. Here, we first developed a novel immunological AuNP through intracellular generation and exocytosis for combinatorial PTT and immunotherapy. Melanoma B16F10 cells were employed to generate AuNPs first and then shed nanoparticle trapped vesicles to extracellular environment with retained tumor antigens (AuNP@B16F10). By further introducing the nanoparticles into dendritic cells (DCs), DC-derived AuNPs (AuNP@DCB16F10) were generated with enhanced biosafety, which can induce hyperthermia and provoke antitumor immune responses. This immunological nanoplatform demonstrated efficient inhibition or even eradication of primary tumor, tumor metastasis, as well as tumor relapse, with significantly improved overall survival of mice. With our design, the intracellularly generated AuNPs with immunological property could act as an effective treatment modality for cancer.
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