化学
电泳剂
氮丙啶
芳基
亲核细胞
反应性(心理学)
区域选择性
苯乙胺类
烷基
组合化学
Negishi偶联反应
苯乙胺
碘化物
有机化学
偶联反应
光化学
催化作用
戒指(化学)
立体化学
医学
替代医学
病理
作者
Talia J. Steiman,Junyi Liu,Amanuella Mengiste,Abigail G. Doyle
摘要
A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines and commercially available (hetero)aryl iodides is reported. This mild and modular method proceeds in the absence of stoichiometric heterogeneous reductants and uses an inexpensive organic photocatalyst to access medicinally valuable β-phenethylamine derivatives. Unprecedented reactivity was achieved with the activation of cyclic aziridines. Mechanistic studies suggest that the regioselectivity and reactivity observed under these conditions are a result of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the active electrophile. This strategy also enables cross-coupling with Boc-protected aziridines.
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