Effect of saponin extract of Glycyrrihiza glabra in activity of hepatic enzymes and some biochemical parameters in serum of adults ovariectomized female rats

This research was planned to verify the influence of saponin, that extracted from Glycyrrihiza glabra in activity of hepatic enzymes and some biochemical parameters of serum ovariectomized adult female rats. 15 adult female rats were randomly divided into three groups, which included sham-operated (sham), ovariectomized (ovx), and ovariectomized rats treated orally with (250 mg/kg/day) of saponin extract for (25) days. The results revealed, that ovx rats showed a significant elevation in alkaline phosphatase (ALP) activity, Calcium level, a significant reduction in activities of creatine kinase (CK), aspartate amino transferase (AST), γ-Glutamyl transferase (GGT), and level of albumin, creatinine without any significant change in alanine amino transferase (ALT) activity and magnesium level comparison with sham -operated rats. Treatment ovx rats with 250 mg/kg of saponin caused a significant reduction in ALT and CK activities, and elevation in albumin and creatinine levels, and AST, GGT activities. In conclusion, the present results revealed that, saponin extracted of Glycyrrihiza glabra have an effect in hepatic enzyme activity and some biochemical parameters in ovariectomized female rats with osteoporosis results from reduction in estrogen level.