Clinical Applications and Advances of Thrombopoietin Receptor Agonist

Thrombocytopenia is a common clinical disorder,which could be found in hematological and non-hematological diseases.With significant advances in thrombopoietic agents,the application of thrombopoietin receptor agonist (TPORA),romiplostim and eltrombopag,could effectively increase the platelet count of patients,and provide a new treatment for thrombocytopenia.This article review the literatures on the mechanisms and clinical use of TPORA in hematological disorders and thrombocytopenia related to hepatopathy. Key words: Thrombopoietin receptor agonists;  Romiplostim;  Eltrombopag; Thrombocytopenia ;  Drug therapy