医学
生物年龄
疾病
心理干预
老年学
人口老龄化
寿命
人口
健康衰老
重症监护医学
老化
病理
环境卫生
内科学
精神科
作者
Magda R. Hamczyk,Rosa M. Nevado,Ana Barettino,Valentín Fuster,Vicente Andrés
标识
DOI:10.1016/j.jacc.2019.11.062
摘要
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.
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