受体
生物
G蛋白偶联受体
免疫系统
人类健康
嗅觉
炎症
食欲
嗅觉系统
神经科学
生物化学
免疫学
医学
内分泌学
环境卫生
作者
Rifat Nowshin Raka,Hua Wu,Junsong Xiao,Imam Hossen,Yanping Cao,Mingquan Huang,Jian-Ming Jin
标识
DOI:10.1080/10408398.2021.1885007
摘要
Ectopic olfactory receptors (EORs) are expressed in non-nasal tissues of human body. They belong to the G-protein coupled receptor (GPCR) superfamily. EORs may not be capable of differentiating odorants as nasal olfactory receptors (ORs), but still can be triggered by odorants and are involved in different biological processes such as anti-inflammation, energy metabolism, apoptosis etc. Consumption of strong flavored foods like celery, oranges, onions, and spices, is a good aid to attenuate inflammation and boost our immune system. During the digestion of these foods in human digestive system and the metabolization by gut microbiota, the odorants closely interacting with EORs, may play important roles in various bio-functions like serotonin release, appetite regulation etc., and ultimately impact health and diseases. Thus, EORs could be a potential target linking the ligands from food and their bioactivities. There have been related studies in different research fields of medicine and physiology, but still no systematic food oriented review. Our review portrays that EORs could be a potential target for functional food development. In this review, we summarized the EORs found in human tissues, their impacts on health and disease, ligands interacting with EORs exerting specific biological effects, and the mechanisms involved.
科研通智能强力驱动
Strongly Powered by AbleSci AI