Human T Cell Clones: A New Approach to Immune Regulation

Session I: T Cell Receptors.- Molecular and Functional Analysis of the Human T Cell Antigen/MHC Receptor.- The Murine T Cell Receptor.- The Genes of the Murine T Cell Receptor.- Molecular Studies of the Human T-Cell Antigen.- Session II: HLA Antigens and their Recognition.- Cloned HLA-D Genes: Characterization and Approaches to Expression and Analysis of Function.- SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-T3 and Anti-T4 Antibodies.- Recognition of HLA Class II Molecules by Functional Human T-Lymphocyte Clones (TLC's).- Restriction Elements on Class II HLA Molecules Studied by Cloned Human T4 Cells.- Molecular and Functional Analysis of HLA-Class II Molecules Responsible for the Primary MLR in Man.- HLA-Class I Antigen Recognition by EB Virus-Specific and Allo-Specific Cytotoxic T Cells.- Session III: Clones Recognizing Extrinsic Antigens.- Antigen Recognition by Human Influenza Virus Specific Helper T Lymphocyte Clones.- Exogenous IL-2 Independent Antigen-Specific Human T Cells: Antigen-Specific Induction of Polyclonal B. Cell Factors.- Probing a Repertoire of T Cells Responding to a Mycobacterial Antigen.- Accessory Cell Requirements for the Proliferation of Antigen Specific Human T Cells.- Nickel-Specific Human T Cell Clones: Functional Characterization and Requirements for Triggering.- Session IV: Role of Cell Surface Molecules in T Cell Function.- Human Lymphocyte Functional Antigens.- Cell Surface Antigens Involved in Human Cytolytic T Lymphocyte-Mediated Cytolysis.- MHC-Restricted Antigen-Receptor Specific Regulatory T Cell Circuits in Man.- Early Biochemical Events in T Lymphocytes Activated by Anti-T3.- Surface Structures Involved in Human Cytolytic T Lymphocyte Function.- Section V: T Cell Clones and the Analysis of Disease.- Manipulation of Autoimmune Diseases Using Autoimmune T Lymphocytes.- Cloning of Autoimmune T Cells: Implications for Pathogenesis and Therapy.- Self Education After Mismatched HLA Haploidentical Bone Marrow Transplantation.- Human T-Cell Leukemia Viruses, T-Cell Leukemia, and AIDS.- Session VI: Immuneregulation.- Autoregulation of T-Cell Profliferation.- Interleukin-2 Receptors.- Response of T Cells to Synthetic Peptide Antigens: Specific Unresponsiveness Analogous to Tolerance.- Antigen-T Lymphocyte Interactions in the Induction of Functional Unresponsiveness.- Pathways and Mechanisms of Human T Cell Activation.- Loss of Alloreactivity Associated with Acquired Suppressive and Natural Killer-Like Activities of Aged T Cell Clones.- Phorbol Ester Induced Modulation of Lymphocyte Phenotype and Function.- Session VII: Regulatory Factors Produced by T Cell Clones.- Regulation of Growth and Differentiation of Human B Cells.- Antigen-Specific T Cell Helper Factors.- Human T-Cell Hybrids Producing Antigen Specific Helper Factors.- Influenza Specific Cytotoxic T-Cell Clones and Immune Interferon.- The Il-1 Pathway in T Cell Activation.- Session VIII: T Cell Clones and Anti-Tumor Immunity.- T Cell Clones Recognizing Autologous Tumour Cells.- Cell Surface Determinants Associated With the Interaction of Human CTL Clones and Autologous Tumor.- T3? and T3+ Cloned Cytotoxic Lymphocytes: Functional and Phenotypic Characteristics.- Murine and Human Tuberculin Reactive T Helper Clones: their Role in Anti-Tumor Immunity.