It is not easy to identify the exact pain-producing structures in degenerative spinal diseases. Intervertebral disc, facet joint and sacroiliac joint have been widely known as major causes of chronic low back pain (LBP) and referred pain. The afferent sympathetic fibers that pass through the L2 spinal nerve root are the cardinal pathway of sensation from the above three structures. Here, we discuss the effectiveness of L2 nerve root block for patients who are suffering from LBP and referred pain with compound causes.