促肾上腺皮质激素释放激素
激素
内科学
内分泌学
食物摄入量
神经肽
食欲
心理学
神经递质
医学
中枢神经系统
受体
作者
John R. Glowa,James H. Barrett,Jonetta Russell,Phil Gold
出处
期刊:Peptides
[Elsevier]
日期:1992-05-01
卷期号:13 (3): 609-621
被引量:77
标识
DOI:10.1016/0196-9781(92)90097-m
摘要
Corticotropin releasing hormone (CRH) is a 41-residue hypothalamic neuropeptide that has been shown to have potent behavioral effects in animals and has been implicated in clinical disorders in man. This review focuses on those aspects of the behavioral effects of CRH related to food-associated behaviors. The effects of CRH on food intake are compared with its effects on performances maintained by food presentation, and contrasted with the effects of CRH on performances maintained by other events. The effects of CRH antagonists and drugs that interact with the behavioral effects of CRH are also reviewed, particularly with respect to their direct effects on food intake. Lastly, data assessing the effects of CRH administration on central neurotransmitter levels are presented and compared with levels seen in clinical populations. The effect of CRH on food intake seen in animals is consistent with a putative role for CRH in clinical syndromes where appetite suppression is apparent. Since some of the effects of CRH on food intake are subject to pharmacological intervention, strategies directed at peptidergic mechanisms of psychiatric disorders should be explored.
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