Objective: Accumulating data indicate that thiazolidinediones (TZD) present beneficial effects for the cardiovascular system beyond glycemic control, such as triglyceride reduction, HDL-cholesterol elevation and decrease in plasminogen activator inhibitor-1 levels. The aim of this study was to determine the effect of rosiglitazone on C-reactive protein, an inflammation marker associated with an increased risk for cardiovascular disease, in patients with hypertension and Type 2 diabetes.