乙二醇
纳米颗粒
银纳米粒子
PEG比率
胶体
聚合物
化学
化学工程
水溶液
动态光散射
拉曼光谱
离子强度
共价键
材料科学
纳米技术
有机化学
经济
财务
工程类
物理
光学
作者
Andriy Shkilnyy,Martin Soucé,Pierre Dubois,Fabienne Warmont,Marie‐Louise Saboungi,Igor Chourpa
出处
期刊:Analyst
[The Royal Society of Chemistry]
日期:2009-01-01
卷期号:134 (9): 1868-1868
被引量:83
摘要
The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids of silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due to steric repulsion between polymer-modified surfaces, the stability of the nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At the same time, the PEG coating remains sufficiently permeable to allow surface-enhanced Raman scattering (SERS) from micromolar concentrations of small molecules such as the anticancer drug mitoxantrone (MTX). The enhancement efficiency of the hot spot-free Ag-PEG was compared to that of citrate-stabilized Ag colloids used after pre-aggregation. The potential of the polymer-stabilized colloids developed in this study is discussed in terms of bioanalytical applications of SERS spectroscopy.
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