Influence of adrenaline on the diabetogenic effect of alloxan in the rat

Abstract The effect of alloxan and adrenaline on blood glucose was investigated in 84 rats. The diabetogenic action of alloxan, 200 mg/kg, was prevented by mixing it for 10 min with adrenaline, 50 μg/kg, before injection. No histological changes in the islets were observed after the injection of this mixture. Similar doses of adrenaline and alloxan, injected intramuscularly at the same time but separately produced a diabetogenic action greater than that produced by alloxan alone.