医学
内科学
心脏病学
瘦素
左心室肥大
射血分数
神经肽Y受体
内分泌学
血压
肌肉肥大
体质指数
心室肥大
心力衰竭
肥胖
神经肽
受体
作者
Carmine Zoccali,Francesca Mallamaci,Giovanni Tripepi,Francesco Benedetto,Saverio Parlongo,Sebastiano Cutrupi,Graziella Bonanno,Francesco Rapisarda,Pasquale Fatuzzo,Giuseppe Seminara,Alessandro Cataliotti,Lorenzo Malatino
标识
DOI:10.1097/00004872-200307000-00025
摘要
Neuropeptide Y (NPY) is released during sympathetic stimulation and mediates the central effects of the adipostatic hormone leptin. The plasma concentration of NPY and leptin is increased in patients with end stage renal disease (ESRD), but it is unknown whether these substances are related to biochemical markers of sympathetic activity and to alterations in left ventricular (LV) mass and function in these patients.We investigated the relationship between NPY, norepinephrine (NE), leptin and echocardiographic measurements in a cross-sectional study in 198 patients with ESRD.NPY was directly related to plasma NE and heart rate but it was largely independent of arterial pressure and of retention of metabolic waste products. NPY was significantly higher in patients with LV hypertrophy and in those with LV systolic dysfunction than in those without these alterations. Of note, NPY emerged as an independent correlate of LV mass index and of LV ejection fraction (LVEF) (both P
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