The up to date progress of the microfluid based lab on a chip and it's functionality were reviewed. The relationship between microfluid based lab on a chip and capillary electrophoresis, the main parts of the functional microfluid based lab on a chip, and the general functions of this technology were described. Special attention was paid to the application of this lab on a chip in the field of ultra high throughout drug screening. The research progress of the author's laboratory in this field was introduced as well.