Role of the brain-gut axis in pathogenesis of irritable bowel syndrome

The mechanism of irritable bowel syndrome(IBS) may be related to such factors as abnormal intestinal motility,visceral hypersensitivity,infection,psychological factors and so on.The role of brain-gut axis has caused widespread concern,and the risk factors mentioned above can be illuminated in the framework of brain-gut interaction.Consequently,brain-gut axis becomes the breakthrough point to research the pathogenesis of IBS.In this article,we will review the role of brain-gut axis in the pathogenesis of IBS from the following aspects: the concept of brain-gut axis,the mechanism of its action,the abnormality of brain-gut axis in IBS incidence,and targeted therapy.