Objective To investigate the clinical efficacy for minimally invasive percutaneous nephrolithotomy lithotomy in the kidney stones after open surgery.Methods 48 patients of hospitalized open surgery with a history of kidney stones from February 2010 to June 2011 were randomly divided into the MPCNL group and PCNL group,and they were taken with minimally invasive percutaneous nephrolithotomy stone surgery(with MPCNL) and percutaneous nephrolithotomy lithotomy(PCNL),of which 31 cases were in left and right side was in 17 cases,25 cases were of single stones,and multiple stones were in 18 patients,five cases were of staghorn calculi,and calculus volume was 4.0~25.0cm3.The postoperative clinical results and complications were compared.Results The hospitalized time in MPCNL group of patients was significantly shorter than PCNL group(P0.05),and the average operative time and average cost of hospitalization were no statistically significant(P0.05).The average of stones cleared in the MPCNL group of patients was 81.8%,significantly higher than in the PCNL group with 64.4%.The recurrence rate of the MPCNL group was 4.0%,significantly lower than the the PCNL group of 13.1%(P0.05).The post-operative complications in the MPCNL group of patients was 8.0%,significantly lower than PCNL group of 26.1%(P0.05).Conclusion The clinical efficacy for MPCNL in the treatment of kidney stones or recurrent aspects with open surgery is good,with tissue trauma and low complication rate.