Objective To explore the relationship of local cerebral glucose metabolism decrease and local cerebral blood flow, decrease with cerebral infarction. Methods The results of cerebral (superscript 18)F-FDG PET images and (superscript 99m)Tc-ECD cerebral blood flow images in 30 patients with multiple cerebral infarction were analyzed retrospectively. Results Local cerebral glucose metabolism decrease was positively related to clinical manifestations, and also to infarction position and local cerebral blood flow decrease. Conclusions (superscript 18)F-FDG PET images can provide the evidence for the diagnosis and treatment of ischemic cerebrovascular diseases.