A Simple PLGA-AgNPL Film for Antibiofilm Formation by Contact Bactericidal Activity

A PLGA-AgNPL film was fabricated to demonstrate antibiofilm formation activity against Staphylococcus aureus. The film with a PLGA concentration of 25 mg mL−1 with 0.1% silver nanoplates showed promising (94%) reduction of biofilm formation. The PLGA-AgNPL film did not produce many silver ions. The mode of action of the film was hypothesized to be contact killing when bacteria were attached to the surface to commence biofilm formation.