自愈水凝胶
乙烯醇
光引发剂
组织工程
壳聚糖
光致聚合物
高分子化学
化学工程
化学
材料科学
聚合物
聚合
复合材料
生物医学工程
有机化学
单体
工程类
医学
作者
Yingshan Zhou,Shuyan Zhao,Can Zhang,Kaili Liang,Jun Li,Hongjun Yang,Shaojin Gu,Zikui Bai,Dezhan Ye,Weilin Xu
标识
DOI:10.1016/j.carbpol.2018.01.009
摘要
Photocrosslinkable hydrogels composed of natural materials exhibit great application potential in tissue engineering scaffolds. However, weak formation and poor mechanical property can usually be a limitation. Herein, the photo-clickable thiol-ene hydrogels based chitosan were synthesized using photopolymerization of maleic chitosan (MCS) and thiol-terminated poly (vinyl alcohol) (TPVA) in the presence of a biocompatible photoinitiator. Rheological property and absorbing behavior of the MCS/TPVA hydrogels could be tailored by varying the amount of TPVA in the feed. There was strong intermolecular hydrogen bonding between the molecules of MCS and TPVA. Notably, the MCS/TPVA hydrogel (MT-3) exhibited rapid gelation behavior (<120 s), improved stiff (G' = ∼5500 Pa) and compressive strength (0.285 ± 0.014 MPa), which were important for hydrogel scaffolds, especially for injectable hydrogel scaffolds. Photocrosslinked MCS/TPVA hydrogels was cytocompatible and could promote the L929 cells attachment and proliferation, showing their potential as tissue engineering scaffolds.
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