维蒂希反应
化学
有机化学
酒精氧化
波动性(金融)
组合化学
催化作用
金融经济学
经济
作者
Qiang‐Qiang Li,Zaher Shah,Jian‐Ping Qu,Yan‐Biao Kang
标识
DOI:10.1021/acs.joc.7b02720
摘要
A base-promoted transition metal-free approach to substituted alkenes using alcohols under aerobic conditions using air as the inexpensive and clean oxidant is described. Aldehydes are relatively difficult to handle compared to corresponding alcohols due to their volatility and penchant to polymerize and autoxidize. Wittig ylides are easily oxidized to aldehydes and consequently form homo-olefination products. By the strategy of simultaneously in situ generation of ylides and aldehydes, for the first time, alcohols are directly transferred to olefins with no need of prepreparation of either aldehydes or ylides. Thus, the di/monocontrollable olefination of diols is accomplished. This synthetically practical method has been applied in the gram-scale synthesis of pharmaceuticals, such as DMU-212 and resveratrol from alcohols.
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