Iridium‐Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

Abstract Iridium‐catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram‐scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f‐amphox catalyst with 99% yield and >99% ee. magnified image