不可逆电穿孔
医学
电穿孔
细胞外基质
烧蚀
病理
肿瘤消融
细胞生物学
内科学
生物化学
生物
基因
化学
作者
Alette H. Ruarus,Laurien G. P. H. Vroomen,Robbert S. Puijk,Hester J. Scheffer,Barbara M. Zonderhuis,Geert Kazemier,M. Petrousjka van den Tol,Ferco H. Berger,Martijn R. Meijerink
标识
DOI:10.1016/j.carj.2017.10.005
摘要
Hepatopancreaticobiliary tumours are often diagnosed at an advanced disease stage, in which encasement or invasion of local biliary or vascular structures has already occurred. Irreversible electroporation (IRE) is an image-guided tumour ablation technique that induces cell death by exposing the tumour to high-voltage electrical pulses. The cellular membrane is disrupted, while sparing the extracellular matrix of critical tubular structures. The preservation of tissue integrity makes IRE an attractive treatment option for tumours in the vicinity of vital structures such as splanchnic blood vessels and major bile ducts. This article reviews current data and discusses future trends of IRE for hepatopancreaticobiliary tumours.
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