Rapidly progressive glomerulonephritis due to coexistent anti-glomerular basement membrane and anti-myeloperoxidase antibody

Rapidly progressive glomerulonephritis (RPGN) is usually accompanied by microscopic glomerular crescent formation with progression to renal failure within weeks to months. RPGN is relative rare and affecting 10% to 15% of patients with glomerulonephritis (GN). The antineutrophlil cytoplasmic antibody (ANCA)-associated RPGN are responsible for more than 80% of the cases. On the other hand, type 4 double-antibody positive diseases are extremely rare, account less than 1% of RPGN, and have features of both type 1 and 3 (Table 1). Here, we report a clinical case of RPGN proved by renal biopsy (Figure. 1) and serological test, we confirmed this rare double antibodies positive type 4 RPGN in this patient