锡尔图因
SIRT3
生物
背景(考古学)
线粒体
西妥因1
炎症
NAD+激酶
肾脏疾病
细胞生物学
生物信息学
内分泌学
免疫学
生物化学
下调和上调
基因
古生物学
酶
作者
Marina Morigi,Luca Perico,Ariela Benigni
出处
期刊:Journal of The American Society of Nephrology
日期:2018-04-30
卷期号:29 (7): 1799-1809
被引量:228
标识
DOI:10.1681/asn.2017111218
摘要
Sirtuins belong to an evolutionarily conserved family of NAD + -dependent deacetylases that share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammalians express seven sirtuins (SIRT1–7) that are localized in different subcellular compartments. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, diabetes, cancer, and aging. In the kidney, the most widely studied sirtuin is SIRT1, which exerts cytoprotective effects by inhibiting cell apoptosis, inflammation, and fibrosis together with SIRT3, a crucial metabolic sensor that regulates ATP generation and mitochondrial adaptive response to stress. Here, we provide an overview of the biologic effects of sirtuins and the molecular targets thereof regulating renal physiology. This review also details progress made in understanding the effect of sirtuins in the pathophysiology of chronic and acute kidney diseases, highlighting the key role of SIRT1, SIRT3, and now SIRT6 as potential therapeutic targets. In this context, the current pharmacologic approaches to enhancing the activity of SIRT1 and SIRT3 will be discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI