An open label pilot trial of Abhaya Ghrita in autistic disorder

Autism is a developmental disorder characterized by impaired social interaction, communication, repetitive behaviors and restricted interests.Autism spectrum disorders (ASD) is a clinically defined behavioral syndrome that manifests in early childhood.In India prevalence rate of ASD is 1.2%.There is a little evidence of any 'cure' for Autism.There is lack of sufficient data regarding Ayurvedic strategy of managing this condition.The present study was aimed to assess the efficacy of "Abhaya ghrita", which contains Brahmi (Bacopa monnieri), Kushta (Saussurea lappa Clarke), Vacha (Acorus calamus Linn), Pippali (Piper longum Linn) etc herbs.In present study, 10 patients with 'Autistic disorder', satisfying the DSM-IV-TR (Diagnostic and statistical manual for mental disorders) diagnostic criteria were selected.Abhaya ghrita (with a dose of 5-10ml) has been given orally twice a day for three months.Total three assessments were taken, before starting treatment, after completion of treatment and after follow up.Criteria of assessment were based on the scoring of 'Indian scale for assessment of Autism (ISAA).Paired't' test was used for statistical evaluation.Abhaya ghrita has provided 10.69% of relief on ISAA, which was considered as clinically unsatisfactory.