生物相容性
阿霉素
细胞毒性
药物输送
先天免疫系统
化学
外周血单个核细胞
葡聚糖
生物高聚物
多糖
壳聚糖
材料科学
生物化学
纳米技术
受体
生物
体外
有机化学
化疗
遗传学
聚合物
作者
Kyung-Woo Lee,Young‐Tae Kwon,Jang‐Sun Hwang,Yonghyun Choi,Kyobum Kim,Hyung‐Jun Koo,Youngmin Seo,Hojeong Jeon,Jonghoon Choi
出处
期刊:ACS omega
[American Chemical Society]
日期:2019-01-09
卷期号:4 (1): 668-674
被引量:32
标识
DOI:10.1021/acsomega.8b02712
摘要
β-Glucan, a polysaccharide biopolymer, is one of the constituents of cell walls of microorganisms, basidiomycetes, and plants. It has pathogen-associated molecular patterns, recognizing specific immune cell receptors and can induce innate immunity and control acquired immunity. β-Glucan has properties of biocompatibility, biodegradability, high stability, and low toxicity; therefore, it can be used as a drug-delivery system and therapeutic target. Taking into account the advantages of β-glucan, we designed porous, hollow β-glucan microparticles (YGlu) with doxorubicin (DOX), an anticancer drug. We confirmed the successful loading of the drugs in YGlu by chitosan and alginate electrostatic attraction (Mat) through scanning electron microscopy, UV–vis spectroscopy, and Fourier transform infrared spectrometry. We also examined the cytotoxicity and efficiency of YGlu/Mat/DOX in MDA-MB-231 cells, HUVEC cells, and human peripheral blood mononuclear cells (PBMCs). In addition, we investigated the effects of YGlu on the secretion of cytokines in PBMCs. These results suggest that the YGlu/Mat/DOX may be utilized as a promising platform for drug delivery.
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