桥接(联网)
二硫键
结合
试剂
同种类的
半胱氨酸
组合化学
化学
抗体
纳米技术
材料科学
计算机科学
生物化学
有机化学
免疫学
生物
酶
热力学
物理
数学分析
数学
计算机网络
作者
Nafsika Forte,Vijay Chudasama,James R. Baker
标识
DOI:10.1016/j.ddtec.2018.09.004
摘要
Antibody-drug conjugates (ADCs) constructed using site-selective labelling methodologies are likely to dominate the next generation of these targeted therapeutics. To this end, disulfide bridging has emerged as a leading strategy as it allows the production of highly homogeneous ADCs without the need for antibody engineering. It consists of targeting reduced interchain disulfide bonds with reagents which reconnect the resultant pairs of cysteine residues, whilst simultaneously attaching drugs. The 3 main reagent classes which have been exemplified for the construction of ADCs by disulfide bridging will be discussed in this review; bissulfones, next generation maleimides and pyridazinediones, along with others in development.
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