肽
药物输送
自愈水凝胶
超分子化学
材料科学
异硫氰酸荧光素
异硫氰酸盐
控制释放
自组装
生物物理学
纳米囊
分子
组合化学
化学
纳米技术
高分子化学
有机化学
纳米颗粒
荧光
生物化学
物理
生物
量子力学
作者
Michal E. Roth-Konforti,Michela Comune,Michal Halperin‐Sternfeld,Irena Grigoriants,Doron Shabat,Lihi Adler‐Abramovich
标识
DOI:10.1002/marc.201800588
摘要
Low-molecular-weight self-assembled peptides may serve as promising hydrogelators for drug delivery applications by changing their structural network in response to external stimuli. Herein, inspired by the well-studied low-molecular-weight peptide hydrogelator, fluorenyl-methoxycarbonyl-diphenylalanine (Fmoc-FF), a novel peptide is designed and synthesized to include an ultraviolet (UV)-sensitive phototrigger. Similar to Fmoc-FF, 6-nitroveratryloxycarbonyl-diphenylalanine (Nvoc-FF) self-assembles to form a 3D, self-supporting, nanofibrous hydrogel. The Nvoc-FF hydrogel exhibits good mechanical properties with a storage modulus of 40 kPa. UV irradiation of the Nvoc-FF hydrogel encapsulating insulin-fluorescein isothiocyanate (insulin-FITC) results in the cleavage of Nvoc-FF peptide to produce unmasked FF, thereby facilitating the degradation of the hydrogel and the release of insulin-FITC. This release is in linear correlation to the irradiation time. In the present study, a first insight into this rigid, fibrous, light-responsive hydrogel is provided, allowing the fabrication of a novel drug delivery system for controlled release of large molecules.
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