表面改性
酰胺
化学
组合化学
激进的
甲酰胺
小学(天文学)
有机化学
天文
物理
物理化学
作者
Nana Tang,Xinxin Wu,Chen Zhu
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:10 (28): 6915-6919
被引量:77
摘要
Development of practical methods for the production of multi-functionalized amides is one of the most important topics in both synthetic chemistry and drug discovery. Disclosed herein is a new, efficient, site-selective heteroarylation of amides via C(sp3)-H bond functionalization. Amidyl radicals are directly generated from the amide N-H bonds under mild conditions, which trigger the subsequent 1,5-HAT process. A wide scope of aliphatic amides including carboxamides, sulfonamides, and phosphoramides are readily modified at remote C(sp3)-H bonds by installing diverse heteroaryl groups. Borne out of pragmatic consideration, this protocol can be used for the late-stage functionalization of amides.
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