原发性震颤
医学
肉毒毒素
交叉研究
弱点
双盲
安慰剂
评定量表
临床试验
物理医学与康复
麻醉
物理疗法
外科
心理学
内科学
替代医学
病理
发展心理学
作者
Shivam Om Mittal,Duarte Machado,D. E. Richardson,Divyanshu Dubey,Bahman Jabbari
标识
DOI:10.1016/j.parkreldis.2018.06.019
摘要
Introduction To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection for treatment of essential hand tremor. In essential tremor and Parkinson's disease tremor, administration of onabotulinumtoxinA via a fixed injection approach improves the tremor but a high percentage of patients (30–70%) develop moderate to severe hand weakness which has limited its use in clinical practice. Methods This study was performed from July 2013 to July 2016 on 33 subjects. This is a double-blind, placebo-controlled, crossover trial injecting 80–120 units of IncoA into 8–14 hand and forearm muscles using a customized approach. The subjects were followed for 28 weeks. The treatment efficacy was evaluated by the Fahn Tolosa Marin tremor rating score and NIH genetic criteria for tremor severity at 4 and 8 weeks after each of the two sets of treatments. Hand strength was assessed by an ergometer. Results There was statistically significant improvement in clinical rating score of tremor at 4 and 8 weeks following the IncoA injection. Conclusion In this study, injection of IncoA treatment via a customized approach improved essential tremor on the clinical scales and patient's perception with a low occurrence of significant hand weakness.
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