肝保护
化学
抗氧化剂
超氧化物歧化酶
谷胱甘肽过氧化物酶
过氧化氢酶
碱性磷酸酶
四氯化碳
多糖
药理学
四氯化碳
生物化学
谷胱甘肽
酶
生物
有机化学
作者
Xichuan Zhai,Caiping Zhu,Zhou Yang,Jingru Sun,Aamina Alim,Xingbin Yang
标识
DOI:10.1016/j.carbpol.2018.09.013
摘要
This proposed work aimed to investigate the chemical characteristic, antioxidant capacities and hepatoprotection effect of pomegranate peel polysaccharides (PPP) on CCl4-induced oxidative damage in mice. PPP was identified as the acidic heteropolysaccharides by HPLC methods. In vitro test showed that PPP had excellent reducing power and scavenging effects against free radicals. Administration of PPP (50, 100 and 200 mg/kg·bw) in mice before the injection of CCl4 could observably antagonize the increased serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and hepatic malonaldehyde level in CCl4-induced mice, especially administrated with 200 mg/kg·bw of PPP. Hepatic enzymatic activities of total superoxide dismutase, glutathione peroxidase, catalase and non-enzymatic activity of glutathione were markedly increased at high dosage of PPP, respectively. In addition, histopathological observation of liver further proved these biochemical characteristics. Therefore, it can be concluded that PPP exhibits strong protective effects against CCl4-induced liver injury in mice.
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