互补性(分子生物学)
序列(生物学)
计算机科学
互补决定区
计算生物学
蛋白质数据库
网站
集合(抽象数据类型)
数据挖掘
蛋白质结构
生物信息学
抗体
生物
万维网
互联网
遗传学
程序设计语言
单克隆抗体
生物化学
作者
Mark B. Swindells,Craig T. Porter,M. Couch,Jacob Hurst,K. R. Abhinandan,Jens Hedegaard Nielsen,Gary Macindoe,James Hetherington,Andrew C.R. Martin
标识
DOI:10.1016/j.jmb.2016.08.019
摘要
abYsis is a web-based antibody research system that includes an integrated database of antibody sequence and structure data. The system can be interrogated in numerous ways—from simple text and sequence searches to sophisticated queries that apply 3D structural constraints. The publicly available version includes pre-analyzed sequence data from the European Molecular Biology Laboratory European Nucleotide Archive (EMBL-ENA) and Kabat as well as structure data from the Protein Data Bank. A researcher's own sequences can also be analyzed through the web interface. A defining characteristic of abYsis is that the sequences are automatically numbered with a series of popular schemes such as Kabat and Chothia and then annotated with key information such as complementarity-determining regions and potential post-translational modifications. A unique aspect of abYsis is a set of residue frequency tables for each position in an antibody, allowing “unusual residues” (those rarely seen at a particular position) to be highlighted and decisions to be made on which mutations may be acceptable. This is especially useful when comparing antibodies from different species. abYsis is useful for any researcher specializing in antibody engineering, especially those developing antibodies as drugs. abYsis is available at www.abysis.org.
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