乙烯醇
光热治疗
自愈水凝胶
壳聚糖
抗菌活性
碳纳米管
木质素
材料科学
光热效应
伤口愈合
化学
聚合物
纳米技术
高分子化学
复合材料
细菌
有机化学
医学
生物
免疫学
遗传学
作者
Yeyan Chao,Shengkai Yu,Hua Zhang,Dirong Gong,Jingrui Li,Fan Wang,Jing Chen,Jin Zhu,Jing Chen
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-03-09
卷期号:6 (4): 1525-1535
被引量:12
标识
DOI:10.1021/acsabm.2c01061
摘要
With the development of antimicrobial resistance, rapid and effective killing of bacteria is required for infected wound healing after skin trauma. Herein, we reported a one-pot reaction strategy to prepare a composite hydrogel with antibacterial activity through high-efficiency photothermal therapy. We take poly(vinyl alcohol) as the matrix, and lignin-derived from biomass was introduced into the hydrogel to increase the tensile strength of the prepared hydrogel to 108.58 kPa, and the elongation at break reaches 200.8%. The electrostatic interaction between lignin and chitosan enhanced the reactivity of lignin. Carbon nanotubes endow the hydrogel with photothermal antibacterial activity that can kill more than 97% of either Escherichia coli or Staphylococcus aureus within 5 min, avoiding the problem of bacterial resistance. Experimental evaluation on mice showed that the hydrogel could effectively promote wound healing of full-thickness skin defects. The hydrogels with good mechanical properties, antioxidant activity, and excellent photothermal antibacterial ability show good potential to repair the damaged tissue and are expected to be used in the clinical transformation of wound dressing.
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