Halogen‐Bonding Organocatalysis – New Opportunities for Asymmetric Synthesis

Halogen-bonding catalysis utilizes molecules with electron-deficient halogen atoms as Lewis acid catalysts. Early proof-of-principle studies have demonstrated this to be a viable strategy and now a growing number of studies are attempting to take advantage of halogen bonds (XBs) in asymmetric synthesis. The chapter details the first steps taken to render XB catalysis enantioselective, the current state of the art, and possible future directions worth exploration in the field of asymmetric organocatalysis.