神经炎症
小胶质细胞
蛋白激酶B
MAPK/ERK通路
一氧化氮
一氧化氮合酶
药理学
磷酸化
炎症
肿瘤坏死因子α
PI3K/AKT/mTOR通路
化学
医学
信号转导
免疫学
内分泌学
生物化学
作者
Tianqi Huang,Dong Zhao,Sangbin Lee,Gyochang Keum,Hyun Ok Yang
出处
期刊:Biomolecules & Therapeutics
[The Korean Society of Applied Pharmacology]
日期:2022-11-25
卷期号:31 (3): 276-284
被引量:1
标识
DOI:10.4062/biomolther.2022.092
摘要
Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved in the development progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The objective of this study was to investigate the effect of SA in microglia neuroinflammation models. Our results demonstrated that SA inhibited secretion of the nitric oxide (NO) and interleukin (IL)-6, reduced the expression of inducible nitric oxide synthase (iNOS) and enhanced the release of IL-10 in a dose-dependent manner. Besides, our further investigation revealed that SA attenuated the phosphorylation of AKT and MAPK cascades in LPS-induced microglia. Consistently, oral administration of SA in mouse regulated the production of inflammation-related cytokines and also suppressed the phosphorylation of MAPK cascades and AKT in the mouse cerebral cortex. These results suggested that SA may be a possible therapy candidate for anti-inflammatory activity by targeting the AKT/MAPK signaling pathway.
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