Preparation and responsive performance study of AuNPs/RGO-MoO2/GCE composite modified electrodes based on its high sensitivity to acetaminophen and dopamine

To detect acetaminophen (AMP) and dopamine (DA) effectively and rapidly, the Au nanoparticles (AuNPs） were deposited on the surface of glassy carbon electrode (GCE) modified with Molybdenum dioxide-doped Reduced graphene oxide (RGO-MoO2) nanosheets to form AuNPs/RGO-MoO2/GCE composite modified electrode (electrochemical sensor) was prepared The modified electrode was studied regarding its composition, structure and the effect of process parameters such as the electrochemical response characteristics of AMP and DA, the pH value of the buffer, the scan rate, and the sensitivity of both simultaneous detections. The results show that the synergy between AuNPs and RGO-MoO2 nanomaterials can promote the electrochemical reaction of AMP and DA, and the oxidation peak potential differences of the two are greater than 180 mV. The linear ranges of the modified electrode are 0.05–320 μ mol/L for AMP and 0.6–260 μ mol/L for DA, and the detection limits are 7.2 nmol/L and 13 nmol/L (S/N = 3), respectively. The prepared AuNPs/MoO2-RGO/GCE modified electrode has a wider linear range, lower detection limit, excellent reproducibility, stability and selectivity.