Favorable Palliative Effect of 177Lu-FAPI-2286 in Two Breast Cancer Patients With Refractory Bone Pains

We present 2 women with advanced invasive ductal carcinoma who developed skeletal metastases despite extensive treatment, including surgery, chemotherapy, and hormonal therapy. Both patients experienced debilitating pain and were evaluated for bone palliation therapy using 177 Lu-FAPI-2286, after 99m Tc-FAPI-46 scintigraphy showed suitable uptake. Remarkably, both patients reported significant pain relief shortly after treatment. The only adverse effect noted was grade III thrombocytopenia in 1 patient. These cases highlight the potential of 177 Lu-FAPI-2286 in providing rapid and effective palliation for breast cancer patients suffering from refractory pain, suggesting further investigation into its role in theranostics and palliative care. In this report, we also conducted a comprehensive literature review on radio-ligand therapy with 177 Lu-FAPI in breast cancer.