Interleukin (IL)-34 promotes the inflammatory role of IL-1β-producing myeloid cells in pemphigus lesions

IL-1β-producing myeloid cells play a crucial role in the formation of ELS in pemphigus lesions through inflammatory and chemotactic pathways. Keratinocytes contribute to this process by producing IL-34, which fuels local inflammation. These findings offer new insights into pemphigus immunopathogenesis and suggest the IL-34/CSF-1R pathway as a potential therapeutic target.